Best Mattress Stain Removers for Old and Tough Stains
Removing old stains from mattresses can be challenging, but with the right stain remover, you can restore your bedding to a fresh, clean state. This guide reviews top-rated mattress stain removers available on Amazon, focusing on effectiveness against old stains including blood, urine, wine, coffee, and pet odors. Below is a summary table highlighting key features of the best stain removers to help you find the ideal product for your needs.
| Product | Key Features | Safe For Family | Stain Types |
|---|---|---|---|
| Incredible! Stain Remover (16 oz) | Fast-acting, no rinse, removes pet stains & odors, red wine, coffee | Yes | Pet stains, coffee, wine, ink, grease |
| INCREDIBLE! Stain Remover 2 Pack | Powerful spray, works on old/new stains, non-toxic | Yes | Blood, urine, cosmetics, grease |
| Resolve Upholstery Stain Remover (22 oz) | Safe for most fabrics, lifts dirt and odors, fabric-code sensitive | Yes | Dirt, food, unknown upholstery stains |
| Parker and Bailey Blood Stain Remover (16 oz) | Multi-surface, targets tough blood, grease, oil, and wine stains | Yes | Blood, grass, chocolate, coffee, urine, grease |
| Shout Active Enzyme Spray (22 oz) | Triple-acting enzyme formula, penetrates and lifts over 100 stains | Yes | Grass, dirt, blood, red wine, makeup |
Incredible! Stain Remover for Mattress and Upholstery

The Incredible! Stain Remover is designed to tackle a broad variety of stains including pet stains, urine, red wine, coffee, and oils on mattresses and upholstery. Its powerful formula penetrates the stain and odor in seconds without the need for rinsing, washing, or rubbing. This water-based and non-toxic solution is safe for use around children and pets and is effective for saving carpets, rugs, and clothing from permanent stains. Simply spot and blot the stain for instant results.
INCREDIBLE! Stain Remover 2 Pack for Old Stains

This pack doubles the power of the original Incredible! Stain Remover. It is effective on both new and old stains such as blood, red wine, coffee, cosmetics, and pet urine on mattresses and various fabrics. The product boasts fast-acting stain elimination and does not require heavy rubbing or washing, making it convenient for quick spot treatments. Its non-toxic and non-flammable formula ensures safety during household use.
Resolve Liquid Multi-Fabric Cleaner and Upholstery Stain Remover

Resolve’s upholstery cleaner is safe for most household fabrics like polyester, nylon, and cotton blends, but should be tested first on delicate fabrics like velvet or silk. It is designed to gently lift dirt, odors, and stains without causing damage. Ideal for cleaning carpets and mattress fabrics coded with “Ws” or “W,” this stain remover refreshes and restores fabric appearance while targeting tough spots.
Parker and Bailey Blood Stain Remover for Clothes and Mattress

This versatile remover from Parker & Bailey targets a variety of challenging stains including blood, grease, coffee, wine, and baby formula on mattresses, clothing, and upholstery. The formula acts as both a pre-wash and spot treatment, dependable for multiple household stain scenarios. It’s an all-in-one solution that lifts and deodorizes to restore fabric quality.
Shout Active Enzyme Laundry Stain Remover Spray

Shout’s stain remover employs a triple-acting enzyme formula that clings, penetrates, and lifts over 100 different types of stains. This prewash spray is highly concentrated, making it effective against food, drinks, dirt, grass, red wine, and blood stains. Its active enzymes break down complex stain molecules, supporting powerful removal on mattress fabrics and laundry.
Buying Guide for Mattress Stain Removers
When selecting the best mattress stain remover for old stains, consider these important factors to ensure effective cleaning:
- Stain Type Compatibility: Choose removers that specifically target common mattress stains like blood, urine, wine, and pet stains. Enzyme-based formulas excel against organic stains.
- Fabric Safety: Mattresses often feature delicate fabrics or blends. Look for stain removers labeled safe for upholstery, polyester, cotton blends, and confirm suitability with a test spot.
- Ease of Use: Products with spray application and no rinsing needed offer quick and convenient treatment, especially for spot cleaning stubborn old stains.
- Odor Removal: Many stains go hand-in-hand with odors; opt for removers that also neutralize smells instead of masking them.
- Safety and Non-Toxicity: Since mattresses are close to the skin, prefer non-toxic, fragrance-free, and family-safe stain removers, especially with children and pets in the home.
- Multi-Purpose Functionality: Consider products that can be used on various surfaces such as clothes, carpets, and upholstery for added value and versatility.
- Concentration and Size: Higher concentration products or multi-pack offers provide more uses and often better value.
By reviewing stain remover labels for these areas and matching the formula to your mattress fabric and stain problem, you can select an effective product that restores cleanliness and freshness without damaging your bedding.